12CO and 13CO J=3-2 observations toward N11 in the Large Magellanic Cloud

After 30 Doradus, N11 is the second largest and brightest nebula in the LMC. This large nebula has several OB associations with bright nebulae at its surroundings. N11 was previously mapped at the lowest rotational transitions of $^{12}$CO (J=1--0 and 2--1), and in some particular regions pointings of the $^{13}$CO J=1--0 and 2--1 lines were also performed. Using ASTE we mapped the whole extension of the N11 nebula in the $^{12}$CO J=3--2 line, and three sub-regions in the $^{13}$CO J=3--2 line. The regions mapped in the $^{13}$CO J=3--2 were selected based on that they may be exposed to the radiation at different ways: a region lying over the nebula related to the OB association LH10 (N11B), another one that it is associated with the southern part of the nebula related to the OB association LH13 (N11D), and finally a farther area at the southwest without any embedded OB association (N11I). We found that the morphology of the molecular clouds lying in each region shows some signatures that could be explained by the expansion of the nebulae and the action of the radiation. Fragmentation generated in a molecular shell due to the expansion of the N11 nebula is suggested. The integrated line ratios $^{12}$CO/$^{13}$CO show evidences of selective photodissociation of the $^{13}$CO, and probably other mechanisms such as chemical fractionation. The CO contribution to the continuum at 870 $\mu$m was directly derived. The distribution of the integrated line ratios $^{12}$CO J=3--2/2--1 show hints of stellar feedback in N11B and N11D. The ratio between the virial and LTE mass (M$_{\rm vir}$/M$_{\rm LTE}$) is higher than unity in all analyzed molecular clumps, which suggests that the clumps are not gravitationally bounded and may be supported by external pressure. A non-LTE analysis suggests that we are mapping gas with densities about a few 10$^{3}$ cm$^{-3}$.Comment: Accepted to be published in A&A. Figures were degrade

Association between grip strength and diabetes prevalence in black, South Asian, and white European ethnic groups: a cross-sectional study of 418,656 UK Biobank participants

Aims: To quantify the extent to which ethnic differences in muscular strength might account for the substantially higher prevalence of diabetes in black and South-Asian compared with white European adults. Methods: This cross-sectional study used baseline data from the UK Biobank study on 418 656 white European, black and South-Asian participants, aged 40–69 years, who had complete data on diabetes status and hand-grip strength. Associations between hand-grip strength and diabetes were assessed using logistic regression and were adjusted for potential confounding factors. Results: Lower grip strength was associated with higher prevalence of diabetes, independent of confounding factors, across all ethnicities in both men and women. Diabetes prevalence was approximately three- to fourfold higher in South-Asian and two- to threefold higher in black participants compared with white European participants across all levels of grip strength, but grip strength in South-Asian men and women was ~5–6 kg lower than in the other ethnic groups. Thus, the attributable risk for diabetes associated with low grip strength was substantially higher in South-Asian participants (3.9 and 4.2 cases per 100 men and women, respectively) than in white participants (2.0 and 0.6 cases per 100 men and women, respectively). Attributable risk associated with low grip strength was also high in black men (4.3 cases) but not in black women (0.4 cases). Conclusions: Low strength is associated with a disproportionately large number of diabetes cases in South-Asian men and women and in black men. Trials are needed to determine whether interventions to improve strength in these groups could help reduce ethnic inequalities in diabetes prevalence

The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region

The Drosophila genes spalt major (salm) and spalt-related (salr) encode Zn-finger transcription factors regulated by the Decapentaplegic (Dpp) signalling pathway in the wing imaginal disc. The function of these genes is required for cell survival and proliferation in the central region of the wing disc, and also for vein patterning in the lateral regions. The identification of direct Salm and Salr target genes, and the analysis of their functions, are critical steps towards understanding the genetic control of growth and patterning of the Drosophila wing imaginal disc by the Dpp pathway. To identify candidate Salm/Salr target genes, we have compared the expression profile of salm/salr knockdown wing discs with control discs in microarray experiments. We studied by in situ hybridization the expression pattern of the genes whose mRNA levels varied significantly, and uncovered a complex transcription landscape regulated by the Spalt proteins in the wing disc. Interestingly, candidate Salm/Salr targets include genes which expression is turned off and genes which expression is positively regulated by Salm/Salr. Furthermore, loss-of-function phenotypic analysis of these genes indicates, for a fraction of them, a requirement for wing growth and patterning. The identification and analysis of candidate Salm/Salr target genes opens a new avenue to reconstruct the genetic structure of the wing, linking the activity of the Dpp pathway to the development of this epithelial tissueThis work was supported by institutional grants from Fundación Ramón Areces and Banco de Santander to the Centro de Biología Molecular Severo Ochoa. BFU2009-09403, BFU2012-33994, CSD2007-00008 (http://www.mineco.gob.es/portal/site/mineco/). We acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip

Should physical activity recommendations be ethnicity-specific? Evidence from a cross-sectional study of south Asian and European men

Background Expert bodies and health organisations recommend that adults undertake at least 150 min.week−1 of moderate-intensity physical activity (MPA). However, the underpinning data largely emanate from studies of populations of European descent. It is unclear whether this level of activity is appropriate for other ethnic groups, particularly South Asians, who have increased cardio-metabolic disease risk compared to Europeans. The aim of this study was to explore the level of MPA required in South Asians to confer a similar cardio-metabolic risk profile to that observed in Europeans undertaking the currently recommended MPA level of 150 min.week−1.<p></p> Methods Seventy-five South Asian and 83 European men, aged 40–70, without cardiovascular disease or diabetes had fasted blood taken, blood pressure measured, physical activity assessed objectively (using accelerometry), and anthropometric measures made. Factor analysis was used to summarise measured risk biomarkers into underlying latent ‘factors’ for glycaemia, insulin resistance, lipid metabolism, blood pressure, and overall cardio-metabolic risk. Age-adjusted regression models were used to determine the equivalent level of MPA (in bouts of ≥10 minutes) in South Asians needed to elicit the same value in each factor as Europeans undertaking 150 min.week−1 MPA.<p></p> Findings For all factors, except blood pressure, equivalent MPA values in South Asians were significantly higher than 150 min.week−1; the equivalent MPA value for the overall cardio-metabolic risk factor was 266 (95% CI 185-347) min.week−1.<p></p> Conclusions South Asian men may need to undertake greater levels of MPA than Europeans to exhibit a similar cardio-metabolic risk profile, suggesting that a conceptual case can be made for ethnicity-specific physical activity guidance. Further study is needed to extend these findings to women and to replicate them prospectively in a larger cohort.<p></p&gt

Hipparcos red stars in the HpV_{T2} and VI_C systems

For Hipparcos M, S, and C spectral type stars, we provide calibrated instantaneous (epoch) Cousins $V-I$ color indices using newly derived $HpV_{T2}$ photometry. Three new sets of ground-based Cousins $VI$ data have been obtained for more than 170 carbon and red M giants. These datasets in combination with the published sources of $VI$ photometry served to obtain the calibration curves linking Hipparcos/Tycho $Hp-V_{T2}$ with the Cousins $V-I$ index. In total, 321 carbon stars and 4464 M- and S-type stars have new $V-I$ indices. The standard error of the mean $V-I$ is about 0.1 mag or better down to $Hp\approx9$ although it deteriorates rapidly at fainter magnitudes. These $V-I$ indices can be used to verify the published Hipparcos $V-I$ color indices. Thus, we have identified a handful of new cases where, instead of the real target, a random field star has been observed. A considerable fraction of the DMSA/C and DMSA/V solutions for red stars appear not to be warranted. Most likely such spurious solutions may originate from usage of a heavily biased color in the astrometric processing.Comment: 10 figures, 1 electronic table, accepted in A&